News & Press Releases

Aphea.Bio submits applications for first biofungicides VALORIA™ and VIRTUOSA™ for regulatory approval to the EPA (US)

Gent, Belgium, 8 May 2024 - Aphea.Bio, a leading provider of microbial solutions for agriculture, announces the submission of applications for VALORIA™ and VIRTUOSA™ , its first biofungicides, to obtain federal approval from the United States Environmental Protection Agency (EPA). Upon registration, these biofungicides will offer farmers a sustainable, and economically viable, answer to major diseases in wheat, fruit and vegetables.

VALORIA™ and VIRTUOSA™ are the first biofungicides, derived from Aphea.Bio’s unique technology platform APEXbio6 This high-throughput R&D platform accelerates the discovery process of thousands of naturally-occurring micro-organisms, leading to next-generation biostimulant and biocontrol products.

The two new microbial-based biofungicides are designed for foliar application: VALORIA™ for wheat, and VIRTUOSA™ for fruit and vegetables. Based on a Streptomyces strain, they offer advantageous features, such as ease of use, a two-year shelf life at ambient temperatures, and are mixable and compatible with existing agricultural chemicals. Effective against a broad spectrum of diseases, they protect wheat against head blight, yellow rust, leaf blotch, and powdery mildew, and fruit and vegetables against diseases such as grey mold and powdery mildew.

The application submissions follow three years of extensive field testing, conducted by Aphea.Bio and validated by external partners, demonstrating consistent and robust performance both as standalone solutions and within Integrated Pest Management systems In independent trials performed by reputable organizations. Virtuosa surpassed competitor biofungicides in performance. This positions both Valoria and Virtuosa as reliable options for growers looking to replace or supplement their standard practices. All studies confirm that the microbial strain has a very low risk profile, with no adverse effects observed in toxicity studies and no ecotoxicological risks identified.

“We are excited to submit our first biofungicides VALORIA™ and VIRTUOSA™ , for EPA registration. This marks a significant milestone, demonstrating the versatility and efficacy of our technology platform APEXbio6 in delivering not only biostimulants but also biocontrol solutions. We are looking forward to the introduction of more innovative biocontrol products across many crops and countries in the coming years”, says Isabel Vercauteren, CEO of Aphea.Bio

The company will soon proceed with international registrations and file application submissions in the European Union and California. As we await the outcome of the regulatory review process, we continue our commitment to leveraging beneficial microorganisms for crop growth, thus advancing the transition towards sustainable agriculture. VALORIA™ and VIRTUOSA™ : Pending Registration. These products are not currently registered for sale or use in the United States and are not being offered for sale.

About Aphea.Bio

Aphea.Bio is a fully integrated microbial product development company dedicated to food security and ensuring a safe and healthy food chain and is providing novel, science-based solutions to build the agriculture of the future: sustainable, reliable, and profitable. Located in Gent, Belgium, we have a highly dedicated and qualified team of scientist and industry experts. Based on our unique high throughput APEX® R&D platform utilising the untapped microbial space, we have been able to build a broad biostimulant and biocontrol pipeline based on naturally occurring micro-organisms.

We believe that with a fresh and sincere spirit of innovation, result-driven science, and the courage to go off the beaten track, there is fertile ground to develop efficacious biological solutions to help complement or partially replace products in the major chemical indications. To learn more, visit or follow us on LinkedIn at

Aphea Bio
Charlotte Klank
Head of Regulatory Affairs | Communications
[email protected]

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Cautionary Statement Regarding Forward-Looking Statements

This document may contain forward-looking statements, which can be identified by terminology such as 'expect', 'would', 'will', 'potential', 'plans', 'prospects', 'estimated', 'aiming', 'on track' and similar expressions. Such statements may be subject to risks and uncertainties that could cause the actual results to differ materially from these statements. For Aphea.Bio, such risks and uncertainties include risks relating to legal proceedings, regulatory approvals, new product development, increasing competition, customer credit risk, general economic and market conditions, compliance and remediation, intellectual property rights, implementation of organizational changes, impairment of intangible assets, consumer perceptions of genetically modified crops and organisms or crop protection chemicals, climatic variations, fluctuations in exchange rates and/or commodity prices, single source supply arrangements, political uncertainty, natural disasters, and breaches of data security or other disruptions of information technology. Aphea.Bio assumes no obligation to update forward-looking statements to reflect actual results, changed assumptions or other factors.

© Aphea.Bio, Technologiepark Zwijnaarde 21, 9052 Zwijnaarde.

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